Latest Research on Photobiomodulation (PBM) and Low-Level Laser Therapy (LLLT)
The field of photobiomodulation therapy (PBMT)is advancing rapidly, with new studies emerging almost every few days. As researchers continue to explore its applications in fertility, pain management, wound healing, and mental health, the body of evidence supporting its efficacy grows stronger.
This page highlights some of the most recent and relevant studies, including systematic reviews and meta-analyses, demonstrating PBMT’s therapeutic potential. These publications represent just a fraction of the research available, and new data continues to refine our understanding of how PBMT enhances cellular function, promotes healing, and optimizes health outcomes.
We encourage healthcare professionals and those interested in the science behind PBMT to explore these studies and stay informed about the latest developments and protocols. The field is evolving quickly, making this an exciting time for both researchers and practitioners committed to integrating evidence-based laser therapy into patient care.
For a deeper dive into the research, browse the latest studies below. If you’re looking for specific data or have questions about PBMT’s applications, feel free to reach out. There’s much more out there, and the science is only getting stronger.
General Photobiomodulation Research
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation - PMC
Assessing the impact of low level laser therapy (LLLT) on biological systems: a review
Only lasers can be used for low level laser therapy
Female and Male Fertility & Reproductive Health
Laser acupuncture before and after embryo transfer improves ART delivery rates: results of a prospective randomized double-blinded placebo controlled five-armed trial involving 1000 patients - Fertility and Sterility
Effect of Pulsed High-Intensity Laser Therapy on Pain, Adhesions, and Quality of Life in Women Having Endometriosis: A Randomized Controlled Trial
Low-Level Laser Therapy for Improvement of In Vitro Fertilization Outcomes in Patients with Recurrent Implantation Failure: A Randomized Clinical Trial
PhotoBioModulation: Promising Supplement in Women’s Health
Has the time come to include low-level laser photobiomodulation as an adjuvant therapy in the treatment of impaired endometrial receptivity?
The Role of Laser and Microwave in Treatment of Endocrine Disorders: A Systematic Review | Journal of Lasers in Medical Sciences
Effects of 940 nm low-level laser therapy for the treatment of primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial
Metabolomic study combined with the low-level light therapy of Chinese acupuncture points and combined oral contraceptives in treatment of primary dysmenorrhea: A prospective, multicenter, randomized controlled study: Heliyon
The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up
Therapeutic Effects of Low-Level Laser on Male Infertility: A Systematic Review - PMC
PERSONAL OVERVIEW OF THE APPLICATION OF LLLT IN SEVERELY INFERTILE JAPANESE FEMALES
Effect of Intrauterine Laser Therapy at the IVF Success Rate on Infertile Patients with a History of IVF Failure: A Pilot Non-Blinded Study
Low Level Laser Therapy Decreased the Number of Ovarian Follicular Cysts in Polycystic Ovaries Induced Rats.
High-Intensity Laser Therapy (HILT) as an Emerging Treatment for Vulvodynia and Chronic Musculoskeletal Pain Disorders: A Systematic Review of Treatment Efficacy
New Insights into Photobiomodulation of the Vaginal Microbiome—A Critical Review
Pregnancy, Postpartum & Breastfeeding
https://institutobeatrizyamada.com.br/wp/wp-content/uploads/2023/08/Utilization-of-Laser-Therapy-During-Pregnancy_A-Systematic-Review-of-the-Maternal-and-Fetal-Effects-Reported-From-1960-to-2017.pdf
Laser acupuncture effect on fetal well-being during induction of labor | Lasers in Medical Science
Could Photobiomodulation help lactating women and their newborns? - PubMed
Photobiomodulation therapy in the post-operative management of puerperal mastitis-associated breast abscess | Research, Society and Development
Comparison of photobiomodulation with cryotherapy in the immediate postpartum period of parturients with grade I, grade II lacerations and/or episiotomy in reducing perineal and vulvar and edema: A randomized clinical trial - ScienceDirect
Comparison of Therapeutic Ultrasound and Low Level Laser Therapy Over Pain and Scar Health in Post Episiotomy
Effect of Therapeutic Ultrasound Versus Low-Level Laser Therapy on Post-Operative Pain after Cesarean Section
The Application of Low-Level Laser Therapy after Cesarean Section Does Not Compromise Blood Prolactin Levels and Lactation Status | Photomedicine and Laser Surgery
An Effective and Practical Non-Narcotic Technique for Controlling Post-Operative Pain After Cesarean Delivery
Low level Laser Therapy Improves Pain in Post Cesarean Section: A Randomized Clinical Trial
Evaluation of Photobiomodulation Effect on Cesarean-Sectioned Wound Healing" (2023)
Low-Level Laser Therapy Effects on Reducing Surgical Complications and Wound Infection after Cesarean Section - PMC
Influence of Photobiomodulation Therapy Combined with Pelvic Floor Exercises on Postpartum Coccydynia: A Randomized Controlled Trial
Laser acupuncture for refractory coccydynia after traumatic coccyx fracture
Infants & Children’s Health
A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity | Pediatric Research
Role of Low Level Laser Therapy in Pediatric Scald Burns
Evaluation of scars in children after treatment with low-level laser - PubMed
Role Of Low-Level Laser Therapy (Lllt) in the Management of Pediatric Scald Burns | Biores Scientia
Low-level laser therapy for oral mucositis in children with cancer - PubMed
The Impact of Low-Level Laser Therapy on Spasticity in Children with Spastic Cerebral Palsy: A Systematic Review
Autism
Transcranial photobiomodulation in children aged 2–6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology
Effects of Low-Level Laser Therapy in Autism Spectrum Disorder - PubMed
Efficacy of Laser Acupuncture for Children With Autism Spectrum Disorder: Clinical, Molecular, and Biochemical Study - ScienceDirect
Body Contouring
Photobiomodulation therapy with light-emitting diode in stimulating adipose tissue mitochondria - PubMed
Efficacy and safety of a novel combined 1060-nm and 635-nm laser device for non-invasive reduction of abdominal and submental fat - PubMed
Safety and Efficacy of a Noninvasive 1,060-nm Diode Laser for Fat Reduction of the Flanks - PubMed
Neuropathy & Pain
Is It Time to Consider Photobiomodulation As a Drug Equivalent? - PMC
Efficacy of photobiomodulation therapy on Bell's palsy symptoms: a systematic review - PubMed
Effect of High-Intensity Laser Therapy on Carpal Tunnel Syndrome Patients: A Systematic Review and Meta-analysis - PubMed
Short-term therapeutic effects of 890-nanometer light therapy for chronic low back pain: a double-blind randomized placebo-controlled study - PubMed
Parameters and Effects of Photobiomodulation in Plantar Fasciitis: A Meta-Analysis and Systematic Review - PubMed
New generation low level laser effect on masseter muscle oxygenation, bite force and algometric changes in myofacial pain syndrome: a randomised, placebo-controlled clinical trial - PubMed
Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis - PubMed
Wound Healing
Modulation of Gene Expression in Skin Wound Healing by Photobiomodulation Therapy: A Systematic Review of In Vivo Studies" (2021)
Impact of Photobiomodulation on Macrophages and Their Polarization During Diabetic Wound Healing: A Systematic Review" (2022)
Oral Health & Dental
Effect of photobiomodulation in secondary intention gingival wound healing—a systematic review and meta-analysis | BMC Oral Health
Photobiomodulation in dental extraction therapy Postsurgical pain reduction and wound healing
Effect of photobiomodulation on dentin hypersensitivity: a randomized controlled double-blind clinical trial
Does low level laser therapy relieve the pain caused by the placement of the orthodontic separators?--A meta-analysis - PubMed
Low-Level Light Therapy in Orthodontic Treatment: A Systematic Review
Photobiomodulation in Orthodontics: Mechanisms and Clinical Efficacy for Faster Tooth Movement | Cureus
Gut Health and Microbiome
Effects of photo-biomodulation on Gut Microbiota: A Meta-analysis Based on 16S rRNA Sequencing Data (2024)
The effectiveness of photobiomodulation therapy in modulation the gut microbiome dysbiosis related diseases - PMC
“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?
Muscle Recovery
When is the best moment to apply photobiomodulation therapy (PBMT) when associated to a treadmill endurance-training program? A randomized, triple-blinded, placebo-controlled clinical trial - PubMed
